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and I found something kind of interesting. There is some evidence that increasing levels of epinephrine in the bloodstream can actually help with alcohol clearance. That was very surprising to me, and I want to point out

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have the same levels of happiness is actually not true. At least according to the author of the original study. Now what he did not point to is the degree to which that is not true, but he did point to the direction of the result.

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determines the length of a hair or rather what determines how long a hair continues to grow before it ceases growing and eventually falls out. We're going to talk about what regulates those stem cells, what allows them to continue to produce hair or cease producing hair.

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and our feelings of wellbeing. And of course, any discussion about dopamine has to include a discussion about the potential for dopamine induced addiction. Indeed, dopamine lies at the heart of addiction

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It's also of course, a drug that's used recreationally. It's still illegal at least in the United States.

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the Biology of Learning Reimagining Learning through Neuroscience. And at this event, I will be speaking, there will be other speakers as well, and I will be talking about neuroplasticity

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that there's some sort of blood test or other biomarker or even a fingerprint test that would allow you to determine whether or not you have a propensity to be one of these drinkers that has a predisposition for alcoholism.

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There are numerous images online and websites online of so-called Botox fails, where people have gotten too much Botox or the injections have been done too deep or not at the correct locations

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to experts in the biology of hair, and the stem cells that exist in all of us that give rise to our hair growth, and the pigmentation in our hair, and in talking to experts who understand how to halt and even reverse hair loss,

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through action, through deliberate action. Likewise, being focused or encouraging yourself. Working on being focused on whatever activities you happen to be engaged in, positive or negative,

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and certainly for those that are chronic heavy drinkers, what you end up with is a situation in which you have inflammation in multiple places in the brain and body and the desire to drink even more

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I'm not trying to demonize those compounds for their clinical use. What I'm saying is taking stimulants and then engaging in activities that you would like to continue to feel pleasureful is undercutting the process.

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massaging the scalp or putting red light on the scalp. Although red light might do some other things, in general, heating or lighting of the scalp or massaging of the scalp is really designed to increase blood flow to the scalp.

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This paper was published in Science in 2010, and we will provide a link to the paper. This is frankly, a very interesting paper. This paper involved several subjects, or I should say, 2,250 adult subjects.

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and even drinks on different nights or even different weeks, the amount of dopamine that's released is reduced, the amount of serotonin that's released is reduced. So what you're getting is less and less

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There's also the parasympathetic aspect of the autonomic nervous system. This is all just fancy geek speak for the parts of your brain and body, the nerve cells that make you very relaxed. When you're very relaxed, there tends to be vasodilation.

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That's a terrific zero cost way to support us. In addition, please subscribe to the podcast on Spotify and Apple, and on both Spotify and Apple, you can leave us up to a five-star review.

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Well, you could mimic what was done in this study and do 14 degrees Celsius. But for some people that won't be cold enough, for some people that will be too cold. They did look at the release of stress hormones

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Berberine, which is a substance made from tree bark is sometimes called the poor man's metformin. Metformin being the equally effective prescription version of berberine. Or put differently,

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well, then that epinephrin becomes one of excitement. Okay? I'm using a broad brush here, but essentially what you need to know is that, dopamine and epinephrin aka adrenaline are family members.

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And later, we'll get back to this idea of whether or how one acquired their money has any impact on whether or not that money increases their happiness or not.

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I actually opted to live in the laboratory a lot of the time. And by doing that, I had more money to spend on other things that were important to me. Now I did not have a family at the time,

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rise to that hair, because in doing so, you're going to learn all the different components that you can tap into if your goal is to halt the loss of hairs or

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And they did this by looking at things like pupil size and of course where the eyes were looking and so on and so forth. The basic takeaway of this study was the following. And here I'm quoting from the study. Quote "Rather than maximizing shared attention,

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Later, we're going to talk about some approaches to maintaining dopaminergic neuron health and things that we can all do for that. But I will tell you these dopamine neurons

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of money and having money are related to happiness? Certainly, there are people who have a lot of money who are very happy. Certainly, there are people who have very little money who are very happy. And of course, the reverse is also true. There are plenty of people who don't have very much money

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I should mention that there are three main types of alcohol. There's isopropyl, methyl, and ethyl alcohol, and only the last one, ethyl alcohol or ethanol, is fit for human consumption.

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Our species like all species has a main interest, and that's to make more of itself. And it's just about sex and reproduction. It's about forging for resources.

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but there are a couple of important points I'd like to make about that. First of all, what sorts of genes are involved in setting someone down the path of alcoholism or not?

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Then what's interesting is the experimenter will vary the extent to which they have to stick to that choice. So this could be sticking to the choice by receiving that painting to take home.

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This is pretty scary stuff, especially since it's occurring at an age when most of these things are not typically occurring in males. They can occur, but they're not typical of younger males in their 20s and 30s and early 40s.

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is going to be beneficial to you. And those tools and protocols are going to be health-promoting in any case. If you're learning from and/or enjoying this podcast, please subscribe to our YouTube channel. That's a terrific zero-cost way to support us.

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by the lack of positive visual and auditory cues in their environment. But for most people, we are in what I would call a dynamic relationship with our environment.

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of the cranial facial development, and of course stuff's going on in the brain too, it's along a continuum. So it is possible that some of the changes that occur are more minor,

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I was in college when this whole MPTP thing happened. And I remember hearing this story. At the time, I had no understanding of what it is to have very high levels of dopamine or extremely depleted levels of dopamine.

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No reward. Now, remember this was an activity that prior to receiving a reward, the children intrinsically enjoyed and selected to do.

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and so on and so on. So we need to be a little bit careful or at least nuanced about this statement that money can't buy happiness and that the data support the fact that wealth doesn't determine happiness.

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happiness is or means for us. We can point to certain experiences, we can try and describe our states of mind and body, but most people recognize the feeling when we have it, and we certainly recognize the feeling of not being happy.

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involves learning to access the rewards from effort and doing. And that's hard to do because you have to engage this prefrontal component of the mesolimbic circuit.

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If you stress too much, it can actually make your hair fall out. In fact, I have a cousin who lay down one night stressed, and woke up the next morning , and all of his hair was on his pillow. I'll never forget that story.

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So, for instance, there have been studies of low to moderate red wine consumption. This would be anywhere from one to four glasses per week. And I don't mean enormous glasses,

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So this u-shaped function of people being happier earlier in life and then reporting feeling far less happy and then happiness returning to them, that is, the rising of the u again in their later years, is something that I do believe

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ANDREW HUBERMAN: Welcome to the Huberman Lab podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor

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to access increases in dopamine at different timescales. This turns out to be important to not end up addicted to substances, but it also turns out to be very important to sustain effort

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to the scalp in order to relieve tension of the scalp. In hearing that, it should be obvious why Botox is being used to try and offset hair loss. It's decreasing the squinting,

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for several important reasons. First of all, they ship internationally, because we know that many of you are located outside of the United States. Second of all, and perhaps most important, the quality of their supplements is second to none

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and what constitutes social connection. There are basically two forms of social connection that have been studied and I'll review both, as it relates to increasing our levels of happiness. And the first one is presence and eye contact,

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if that's what you're seeking. And in addition to that, because your yerba mate does appear to have some sort of neuroprotective and a particular dopamine neuron protective properties.

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We don't always get straight A's, sometimes we don't get rewarded with the outcome that we would like. We don't always have the perfect relationship outcome, but understand that your ability to experience motivation

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Frankly, it's hard to make that direct relationship really stick because, you know, it's a question of, you know, how long people inhale, do they have a predisposition to a lung cancer, et cetera.

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with the dopaminergic pathways. And this is largely based on a study that was published some years ago, 2003, but still holds a lot of merit. This is a paper published in proceeds

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Then you run the marathon and you finish, you cross the finish line, you feel great. And you would think, okay, now I'm set for the entire year, I'm going to feel so much better, I'm going to feel this accomplishment in my body,

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and it decreases the sorts of molecules that suppress and combat tumor growth. So, again, even low to moderate amounts of alcohol can be problematic for sake of cancers,

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The reverse is also true, which is that as hair starts to thin, or fall out, or change color, many people expect intense anxiety or even depression.

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food, exercise if that evokes your dopamine. How are we supposed to engage with these dopamine evoking activities in ways that are healthy and beneficial for us? How do we achieve these peaks,

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you will experience very large increases in dopamine. Those increases are transient and very, very intense. And in fact, if you look at the constellation of effects of Macuna Pruriens, what you find is that they're pretty striking

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you don't actually have to see the sun cross down below the horizon, but facing the sun around that time for anywhere from 5 to 10 minutes or even less, even two to five minutes, can adjust the sensitivity of neurons

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but we do not share your email with anybody. We have a very clear and rigorous privacy policy, which is we do not share your email with anybody. And the newsletter comes out once a month and it is completely zero cost.

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but dopamine is released. They will track their clock. Oh, I've been fasting 12 hours, 16 hours, et cetera. They are starting to attach dopamine release or create dopamine release from the deprivation,

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which is the brain's ability to change itself in response to experience. So there's a bit of confusion, and, again, I'm using this episode on alcohol to highlight some of the confusion because I think it's timely,

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Things like sermorelin, which is a peptide that increases growth hormone. It's actually a secreted dog. It causes the secretion of growth hormone and thereby increases in IGF-1. This is well documented. Both growth hormone and IGF-1, as I mentioned, are available by prescription.

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puberty but it's certainly one of the key players. Dihydrotestosterone has these known early roles in embryonic development and in puberty, but what post-finasteride syndrome seems to indicate is

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like eating a little piece of chocolate, if we really liked chocolate, there's some pleasure. But then there's a little bit of pain that exceeds the amount of pleasure, and it's subtle,

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and maybe a little something in the evening, or I'll skip breakfast and do lunch and dinner and so on. Many people are now eating this way in part, because many people find it easier to not eat at all

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signature of happiness. There's no one neural modulator or combinations of neuromodulators that we can say is the cocktail for happiness. But, and it's a very important, but when

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can hire help to clean. You can hire nannies if that's your thing. You can hire help to assist with babysitting or even night nurses if you're having trouble sleeping that will literally

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For those of you that are interested in using micro-needling or micro-needling in combination with chemical treatments like Minoxidil or some of the other treatments we'll talk about in a little bit. Like finasteride and caffeine.

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Might give us, and here it's arbitrary units, x units of dopamine increase. Well, if we buy that article of clothing or we

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I've been meditating for a long time, but I confess sometimes I meditate and sometimes I'm very inconsistent about my meditation. Ideally, I would meditate every day for 20 or 30 minutes,

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as it is when they're 20. There are exceptions to that, of course. Of course, you can adjust the rate of cognitive and physical decline. But in general, people in their 20s feel more physically and mentally vigorous

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However, and this is an important however, that does not mean that administering drugs that increase levels of serotonin in depressed people does not sometimes and indeed often help ameliorate some of their symptoms.

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Which, of course, sets the basis for attention during the day. If you've ever had a poor night's sleep then you are very familiar with how hard it is to focus the following day.

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to be focused primarily on doing experiments and immersing myself in my scientific training. And for me, the even seemingly insignificant interactions of talking to the janitor in the morning

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because I enjoy working out and I enjoy listening to music. I also enjoy listening to podcasts, I also enjoy communicating with people. Those are all wonderful pursuits, but I had layered in too many of them too many times.

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there's been a trend towards increased alcohol consumption, especially in the wake of the pandemic and during the pandemic. Topic for another time. So there's an increase in dopamine and an increase in serotonin,

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But the beauty of this mesolimbic reward pathway that I talked about earlier is that, it includes the forebrain. So you can tell yourself the effort part is the good part. I know it's painful,

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are going to sound, like, pretty typical, right? I mean, nothing that I described so far was about drinking a case a night or about binging on alcohol in the way that we often hear about it in the news. These are pretty common patterns of alcohol consumption.

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the first part of a word tells you where the neurons are. And then the second part tells you where they are connecting to. So when I say nigropstriatal pathway, it means that the neurons are in substantial nigra and they connect to the striatum, nigrostriatal pathway.

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in dopamine 60 minutes after melatonin administration. I've talked before about how viewing bright lights between the hours of 10:00 p.m and 4:00 a.m has been shown in studies by Dr. Samer Hattar,

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there's almost inevitably a crash or a reduction in the baseline in dopamine that we referred to previously. So many people who take Macuna Pruriens

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So for some people, it might even just be helpful to realize that as you try and wean yourself off alcohol or maybe you even go cold turkey, that increased anxiety and feelings of stress

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increasing inflammation just enough at that local site that certain cascades of biological function that relate to proliferation of stem cells or maintenance of stem cell populations are kicked off.

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And here, I'm talking about hypotheticals. But I think we all know people and perhaps ourselves have experienced those kinds of circumstances. So when we talk about happiness we absolutely need to think about resources.